Yoshihide Kanaoka Selected Research

cysteinyl-leukotriene

1/2019	Cysteinyl leukotriene 2 receptor promotes endothelial permeability, tumor angiogenesis, and metastasis.
10/2018	The cysteinyl leukotriene 3 receptor regulates expansion of IL-25-producing airway brush cells leading to type 2 inflammation.
11/2012	Cysteinyl leukotriene 2 receptor on dendritic cells negatively regulates ligand-dependent allergic pulmonary inflammation.
3/2012	Eosinophil-derived leukotriene C4 signals via type 2 cysteinyl leukotriene receptor to promote skin fibrosis in a mouse model of atopic dermatitis.
3/2011	Dectin-2 mediates Th2 immunity through the generation of cysteinyl leukotrienes.
3/2011	Oxidative stress suppresses cysteinyl leukotriene generation by mouse bone marrow-derived mast cells.
1/2009	Dectin-2 recognition of house dust mite triggers cysteinyl leukotriene generation by dendritic cells.
4/2006	Cysteinyl leukotrienes regulate Th2 cell-dependent pulmonary inflammation.
10/2004	Targeted gene disruption reveals the role of the cysteinyl leukotriene 2 receptor in increased vascular permeability and in bleomycin-induced pulmonary fibrosis in mice.
8/2004	Cysteinyl leukotrienes and their receptors: cellular distribution and function in immune and inflammatory responses.

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Yoshihide Kanaoka Research Topics

Disease

16	Inflammation (Inflammations) 01/2021 - 06/2002
14	Asthma (Bronchial Asthma) 01/2018 - 01/2002
9	Pneumonia (Pneumonitis) 05/2016 - 01/2002
4	Fibrosis (Cirrhosis) 03/2012 - 03/2004
3	Neoplasms (Cancer) 01/2019 - 02/2007
3	Respiratory Hypersensitivity 01/2016 - 04/2006
2	Eosinophilia 01/2018 - 10/2009
2	Atopic Dermatitis (Atopic Eczema) 03/2012 - 03/2006
2	type 2C Congenital disorder of glycosylation 10/2009 - 01/2009
2	Hypersensitivity (Allergy) 03/2006 - 01/2002
1	Dermatitis 01/2021
1	Pain (Aches) 01/2021
1	Neoplasm Metastasis (Metastasis) 01/2019
1	Nasal Polyps (Nasal Polyp) 10/2015
1	Polyps 10/2015
1	Pulmonary Eosinophilia (Eosinophilic Pneumonia) 10/2015
1	Sepsis (Septicemia) 10/2011
1	Retinal Neovascularization 02/2011
1	Retinopathy of Prematurity (Retrolental Fibroplasia) 02/2011
1	Macular Degeneration (Age-Related Maculopathy) 02/2011
1	Diabetic Retinopathy (Retinopathy, Diabetic) 02/2011
1	Hypoglycemia (Reactive Hypoglycemia) 03/2010
1	Type 2 Diabetes Mellitus (MODY) 03/2010
1	Atherosclerosis 03/2010
1	Insulin Resistance 03/2010
1	Metaplasia 10/2009
1	Adenoma (Adenomas) 02/2007
1	Colonic Neoplasms (Colon Cancer) 02/2007
1	Globoid Cell Leukodystrophy (Krabbe Disease) 04/2006
1	Gliosis 04/2006
1	Demyelinating Diseases (Demyelinating Disease) 04/2006
1	Arthritis (Polyarthritis) 04/2006
1	Synovitis 04/2006

Drug/Important Bio-Agent (IBA)

15	LeukotrienesIBA 01/2021 - 10/2004
11	cysteinyl-leukotrieneIBA 01/2019 - 03/2004
9	Leukotriene C4IBA 01/2021 - 10/2004
7	Leukotriene D4IBA 01/2021 - 08/2007
7	Leukotriene E4IBA 01/2021 - 08/2007
7	leukotriene D4 receptor (cysteinyl leukotriene receptor)IBA 01/2019 - 03/2004
7	CytokinesIBA 01/2017 - 01/2002
6	LipidsIBA 05/2016 - 01/2002
4	EnzymesIBA 10/2015 - 11/2004
4	Immunoglobulin E (IgE)IBA 02/2014 - 10/2004
4	Prostaglandins DIBA 03/2010 - 01/2002
3	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 01/2018 - 02/2007
3	Interleukin-13IBA 01/2017 - 10/2009
3	mouse dectin-2IBA 02/2014 - 01/2009
3	LipocalinsIBA 03/2010 - 01/2002
3	ProstaglandinsIBA 03/2010 - 04/2006
3	Prostaglandin D2IBA 03/2010 - 04/2006
3	prostaglandin R2 D-isomerase (prostaglandin D2 synthase)IBA 02/2007 - 01/2002
2	erucylphosphocholineIBA 10/2018 - 05/2016
2	Interleukin-33IBA 01/2018 - 10/2015
2	Methacholine Chloride (Methacholine)FDA Link 01/2016 - 04/2006
2	Proteins (Proteins, Gene)FDA Link 10/2015 - 03/2011
2	Glutathione (Reduced Glutathione)IBA 04/2013 - 11/2004
2	LigandsIBA 11/2012 - 01/2009
2	ChemokinesIBA 10/2009 - 01/2009
2	AllergensIBA 10/2009 - 01/2009
2	Blood Proteins (Serum Proteins)IBA 10/2004 - 06/2002
2	Bleomycin (Blenoxane)FDA LinkGeneric 10/2004 - 03/2004
2	ZymosanIBA 10/2004 - 06/2002
2	cysteinyl leukotriene receptor 2IBA 10/2004 - 03/2004
1	p-Methoxy-N-methylphenethylamineIBA 01/2021
1	calcipotriene (calcipotriol)FDA LinkGeneric 01/2021
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2019
1	Texas redIBA 01/2019
1	Dextrans (Dextran)FDA Link 01/2019
1	Interleukin-5 (Interleukin 5)IBA 01/2017
1	Chemotactic FactorsIBA 01/2016
1	Irritants (Vesicants)IBA 01/2016
1	AlarminsIBA 10/2015
1	Prostaglandin-E SynthasesIBA 10/2015
1	AcidsIBA 04/2013
1	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 03/2011
1	Oxygen (Dioxygen)IBA 02/2011
1	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 02/2011
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 02/2011
1	Glucose (Dextrose)FDA LinkGeneric 03/2010
1	Insulin (Novolin)FDA Link 03/2010
1	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 10/2009
1	Adenosine Diphosphate (ADP)IBA 10/2009
1	Arachidonic Acid (Vitamin F)IBA 01/2009
1	Chemokine CCL4IBA 01/2009
1	C-Type Lectins (C-Type Lectin)IBA 01/2009
1	Small Interfering RNA (siRNA)IBA 01/2009
1	purinoceptor P2Y6IBA 01/2009
1	Uridine Diphosphate (UDP)IBA 01/2009
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 11/2007
1	SRS-AIBA 08/2007
1	Prostaglandins EIBA 02/2007
1	4- benzhydryloxy- 1- (3- (1H- tetrazol- 5- yl- )- propyl)piperidineIBA 04/2006
1	piperidineIBA 04/2006
1	AutoantibodiesIBA 04/2006
1	Leukotriene B4IBA 04/2006
1	Immunoglobulin G (IgG)IBA 04/2006
1	Arachidonate 5-Lipoxygenase (5 Lipoxygenase)IBA 04/2006
1	Messenger RNA (mRNA)IBA 04/2006
1	cyclopentenoneIBA 03/2006

Therapy/Procedure

1	Intravenous Administration 04/2006